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2312, 2019

Viral Vector Vaccines Represent a New Frontier in Vaccine Development

By |December 23rd, 2019|Categories: Research & Development|0 Comments

Viral vector vaccines show enormous potential to treat and even eliminate diseases difficult to fight with more traditional vaccines, but developing a proper viral vector vaccine presents a delicate balancing act. Vaccines present one of our strongest tools in fighting - and possibly even eliminating - disease. Inactive and live-attenuated [...]

2212, 2019

Compatibility in Parenteral Liquid Manufacturing

By |December 22nd, 2019|Categories: Manufacturing|0 Comments

Parenteral drug products—those that are intended to be directly introduced to the circulatory system of the patient via injection or infusion, rather than oral dosage via the alimentary canal—must be manufactured under sterile conditions in order to meet pharmaceutical quality standards as described in pharmacopeias. They must also be safe [...]

2112, 2019

Dual-chamber Delivery Systems in Biologics Contract Manufacturing

By |December 21st, 2019|Categories: Manufacturing|0 Comments

Contract manufacturing of biologics poses unique challenges that demand innovative solutions. Most biologics products must be administered as parenterals. However, the liquid form of many biologics are not shelf-stable, requiring them to be formulated as liquids and then lyophilized for storage. Lyophilized products have longer shelf-lives, but they also require [...]

2211, 2019

Different Types of Viral Vectors for Gene Delivery and How They Are Used

By |November 22nd, 2019|Categories: Research & Development|0 Comments

Viruses are appealing vectors for gene delivery because they have evolved over time to deliver nucleic acid directly to specific cells. The same traits that make viruses difficult to treat—their efficiency at targeting particular cells and their ability to avoid immunosurveillance—make them excellent candidates for gene delivery in both research [...]

2111, 2019

What Can We Learn from Non-Touch Techniques for Aseptic Manufacturing?

By |November 21st, 2019|Categories: Manufacturing|0 Comments

Many people who work in the field of aseptic manufacturing may never have heard of aseptic non-touch technique (ANTT). That’s because it was actually pioneered in nursing, where many aseptic techniques “evolved more from anecdotal evidence and ritualistic practice than from empirical research,” according to an article published in the [...]

2011, 2019

Parenteral Contract Manufacturers Design Efficient Processes to Ensure Compliant Products

By |November 20th, 2019|Categories: Manufacturing|0 Comments

The time, equipment, training, and cost required to create compliant parenteral products make outsourcing to parenteral contract manufacturers an attractive option for pharmaceutical companies. Because parenteral drugs bypass the body’s natural defenses, they must be totally sterile upon delivery, which means they must be sterilized completely during manufacture or processed [...]