811, 2018

Sterile Formulation Development Faces Challenges in Blow-Fill-Seal Systems

By |November 8th, 2018|Categories: Research & Development|0 Comments

Developers must consider interactions between the formulation, packaging materials and sterilization measures. For liquid formulations that will be introduced directly into body cavities or tissues, or into the bloodstream, sterility is key to the prevention of infection. The need to maintain sterility in both the formulation and delivery system places [...]

810, 2018

Meeting Challenges in Biologic Fermentation Development

By |October 8th, 2018|Categories: Research & Development|0 Comments

Developing a fermentation process for biologics can be daunting – and rewarding. Biologic pharmaceuticals offer vast new avenues for treating an extensive array of diseases and chronic conditions. As the field has advanced, microbial fermentation has grown in prominence as a biologic production method due to its distinct advantages. This [...]

710, 2018

How Single-Use Instruments are Revolutionizing Biologic Vaccine Development

By |October 7th, 2018|Categories: Research & Development, Uncategorized|0 Comments

Single-use tools may be one of the most effective solutions for avoiding contamination, but they do present several challenges. Contamination can significantly derail the development of a biologic vaccine. When contaminated instruments come into contact with biologic samples, the resulting chemical reactions can ruin the batch by changing the composition [...]

610, 2018

Key Concerns in Microbial Biologic Development

By |October 6th, 2018|Categories: Research & Development|0 Comments

Undaunted by the many challenges posed by biologics processing, developers continue seeking out new techniques. Biopharmaceuticals (or biologics), while not exactly a new technology, are a fascinating and lucrative medical frontier to explore. The first medicine derived from a biological source dates back to the treatment of diphtheria in the [...]

2909, 2018

Current Techniques in Monoclonal Antibody Development

By |September 29th, 2018|Categories: Research & Development|0 Comments

As the complexity of mAbs continues to grow, developers explore the potential of new techniques and expression systems. The development of mAbs (monoclonal antibodies) has come a long way since 1986, when the first mAb, Orthoclone OKT3, received approval for clinical use. Over the past 30 years, mAb production has [...]

2409, 2018

Solid Oral Dosage Vaccine Development and Manufacturing

By |September 24th, 2018|Categories: Manufacturing|Tags: , , , |0 Comments

Challenges of adapting vaccines for oral administration remain significant, but emerging techniques promise greater flexibility and efficiency. Pressures to streamline development and production continue to ramp up in many areas of the pharmaceutical industry. This is particularly true in the field of solid oral dosage forms for vaccines, which now [...]